Coralyne Radiosensitizes A549 Cells by Upregulation of CDKN1A Expression to Attenuate Radiation Induced G2/M Block of the Cell Cycle

Coralyne is a synthetic analog of berberine related to protoberberine-isoquinoline alkaloids. Isoquinoline derivatives and analogs are renowned as potent radiosensitizers with potential medical application. In the present study, we investigated the effect of coralyne on the cell death, cytoskeletal changes and cell cycle progression of irradiated A549 cells. A clonogenic assay revealed that coralyne pretreatment decreased the viability of A549 cells in a time- and dose-dependent manner. Moreover, exposure to coralyne and ionizing radiation (IR) markedly altered the filamentous actin cytoskeletal architecture and integrin-β binding sites of A549 cells. Treatment with 1–25 µM coralyne in combination with 2 Gy of IR significantly reduced the percentage of cells in G2/M phase compared with 2 Gy IR alone. These results indicate that coralyne is a potent radiosensitizing agent that may find an application in medicine.     

Efficient Exact Evaluation of Signs of Determinants

This paper presents a theoretical and experimental study on two different methods to evaluate the sign of a determinant with integer entries. The first one is a method based on the Gram—Schmidt orthogonalization process which has been proposed by Clarkson [Cl]. We review his algorithm and propose a variant of his method, for which we give a complete analysis. The second method is an extension to n × n determinants of the ABDPY method [ABD+2] which works only for 2 × 2 and 3 × 3 determinants. Both methods compute the sign of an n× n determinant whose entries are integers on b bits, by using exact arithmetic on only b +O(n) bits. Furthermore, both methods are adaptive, dealing quickly with easy cases and resorting to full-length computation only for null determinants. Received December 30, 1996; revised September 16, 1998.     

On the convergence condition of generalized root iterations for the inclusion of polynomial zeros

Using a fixed point relation based on the logarithmic derivative of the k-th order of an algebraic polynomial and the definition of the k-th root of a disk, a family of interval methods for the simultaneous inclusion of complex zeros in circular complex arithmetic was established by Petković [M.S. Petković, On a generalization of the root iterations for polynomial complex zeros in circular interval arithmetic, Computing 27 (1981) 37–55]. In this paper we give computationally verifiable initial conditions that guarantee the convergence of this parallel family of inclusion methods. These conditions are significantly relaxed compared to the previously stated initial conditions presented in literature.     

What limits children's working memory span? Theoretical accounts and applications for scholastic development.

Explanations of working memory span in children were studied in a longitudinal follow-up of J. N. Towse, G. J. Hitch, and U. Hutton (1998). Reading span and operation span were lower when within-task retention intervals were lengthened. For each task, variation in span between test waves and age cohorts was systematically related to changes in processing speed. The two spans explained substantial shared variance in both reading and arithmetic scores, with some evidence for domain specificity. Combined span scores predicted unique variance in scholastic attainment over a 1-year interval. The authors concluded that working memory span is constrained by rapid loss of active codes and is not simply a measure of capacity for resource sharing. Working memory is also implicated in scholastic development. (PsycINFO Database Record (c) 2010 APA, all rights reserved)     

若干信号处理的总体设计思路

信号处理是目前电子战技术发展的一个关键技术。不能单纯从信号处理本身来考虑如何实现信号处理 ,必须从系统角度设计信号处理 ,同时结合工作实践对信号处理提出一些建议。     

An interval arithmetic method for the solution of nonlinear systems of equations on a vector computer

We describe a vectorized algorithm for an interval arithmetic Newton-like method for a class of systems of nonlinear equations arising from discretizations of nonlinear elliptic PDE. This method converges to a solution under relatively weak conditions. It is founded on a combination of a Newton-like interval method and interval arithmetic ‘fast’ direct solver. In the present paper we focus our attention on aspects of the vectorization, in particular that of a simulation of an interval arithmetic and that of the direct solver.     

On high-speed computing with a programmable linear array

It has been observed by many researchers that systolic arrays are very suitable for certain high-speed computations. Using a formal methodology, we present a design for a single simple programmable linear systolic array capable of solving large numbers of problems drawn from a variety of applications. The methodology is applicable to problems solvable by sequential algorithms that can be specified as nested for-loops of arbitrary depth. The algorithms of this form that can be computed on the array presented in this paper include 25 algorithms dealing with signal and image processing, algebraic computations, matrix arithmetic, pattern matching, database operations, sorting, and transitive closure. Assuming bounded I/O, for 18 of those algorithms the time and storage complexities are optimal, and therefore no improvement can be expected by using dedicated special-purpose linear systolic arrays designed for individual algorithms. We also describe another design which, using a sufficient large local memory and allowing data to be preloaded and unloaded, has an optimal processor/time product.An earlier version of this paper was presented at Supercomputing '88.This work was partially supported by ONR under the contract N00014-85-K-0046 and by NSF under Grant Number CCR-8906949.     

Semantic extension possibilities in the proposed new fortran

The next revision of the standard Fortran language, commonly referred to as Fortran 8x, has now been published, at least in draft form. It is therefore possible for some of its new features to be investigated and the type of programming that can be expected when implementations appear to be explored. This paper looks at the scope provided by the proposed new features for 'semantic extension' of the language. The capability is illustrated by way of example code which could provide an extended-precision numeric facility if implemented. The new linguistic constructs that permit this type of approach to software provision are described as they are used.     

RS422高速串行通信在AT91RM9200上的实现

针对当前专用RS422设备不能直接移植到AT91RM9200上的问题．利用AT91RM9200芯片上的USART模块，设计开发了RS422高速串行通信模块及其硬件接口电路，并设计了该模块的软件。文中通信模块软硬件的设计．解决了RS422在AT91RM9200上直接移植的问题。在本通信模块的软件设计中，引入了快速CRC冗余校验算法，极大地降低了误码率，提高了通信的可靠性。目前该模块已成功应用于某型导弹导引头等效器的设计中。     

通过平均功率法提高抽油机系统效率

探讨了抽油机平衡度与抽油机系统效率的影响关系,同时分析了抽油机平衡调整的本质和终极目标,提出了一种新的抽油机平衡调整方法——通过对电机功率曲线进行付立叶分析而确定平衡块重心位置的方法。在现场对47口抽油机电机功率曲线进行付立叶分析后实施了调整措施;系统效率提高了3.05%,达到了油田增产降耗、延长系统使用寿命、降低操作成本的目的。